Synthesis and evaluation of metallic nanoparticles-based vaccines against Candida albicans infections

Candida albicans infections have been particularly critical among nosocomial in immune-compromised and hospitalized patients. The interaction of microbes with various types nanoparticles is a crucial stage determining the biological consequences. present study aimed to synthesize evaluate nanomaterial-based vaccines using C. ghosts. silver (Ag-NPs) gold (Au-NPs) were environmentally prepared green chemistry ghosts modified sponge-like protocol. Ag-NPs or Au-NPs cell membrane ghost was confirmed by utilizing Transmission Electron Microscope (TEM), Scanning (SEM), X-Ray Diffraction (XRD) tools. Experimental rats injected different doses mixed their effects on immune system. ions are entirely converted zero-valent atoms due reduction stabilization effect ghost. exhibited small nanosized good monodispersity stable without noticeable agglomeration at room temperature for two months. Enhancement both humoral cellular responses noticed. resulted activation system increased serum levels Interferon Gamma (IFN-?), lymphocyte-derived pro-inflammatory cytokine.